Posts by: Joana Carvalho

Joana Carvalho

Joana holds a BSc in Biology, a MSc in Evolutionary and Developmental Biology and a PhD in Biomedical Sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells — cells that made up the lining of blood vessels — found in the umbilical cord of newborns.

July 20, 2020July 20, 2020

AMN May Be Diagnosis for Patients With Spinal Cord Lesions, Case Report Says

News

Adrenomyeloneuropathy (AMN) should be considered in the differential diagnosis of patients showing signs of spinal cord lesions caused by the loss of myelin, the fatty sheath that wraps around and ... Read more

June 15, 2020June 15, 2020

Autobahn Raises $76M to Advance ABX-002 Candidate for CNS Disorders

News

Autobahn Therapeutics has raised $76 million in Series B funding to advance the development of ABX-002, the company’s lead therapeutic candidate for adrenomyeloneuropathy (AMN) and multiple sclerosis (MS). ABX-002 is ... Read more

April 21, 2020April 21, 2020

Stem Cell Transplant Safe, Effective in Halting Disease Progression in Adult-Onset Forms of ALD, Study Shows

News

Stem cell transplant is a safe and effective procedure to halt disease progression in patients with adult-onset forms of adrenoleukodystrophy (ALD), a study says. The study, “Clinical efficacy of haematopoietic ... Read more

December 3, 2019December 3, 2019

Retina Thickness Linked to Neurodegeneration in Spinal Cord of ALD Patients, Study Finds

News

Thinning of the layer of nerve cells that form the back of the eye, or retina, is linked to neuron degeneration in the spinal cord of people with adrenoleukodystrophy (ALD), ... Read more

October 15, 2019October 15, 2019

Most ALD Patients Without MRI Lesions Retain Normal Cognitive Function, Study Suggests

News

Most men with adrenoleukodystrophy (ALD) who show either minimal or no visible lesions in magnetic resonance imaging (MRI) scans appear to retain normal cognitive abilities, a study has found. The ... Read more

October 1, 2019October 1, 2019

Symptoms of Peroxisomal Disorders Like X-ALD Often Mistaken for Another Disease, Study Finds

News

Peroxisomal disorders, including adrenoleukodystrophy, are evident in a relatively high number of Chinese patients whose symptoms are similar to those caused by hereditary spastic paraplegia (HSP), highlighting the importance of ... Read more

September 3, 2019September 3, 2019

Lack of SIRT1 Likely Contributes to Neuroinflammation in X-ALD, Study Says

News

Lack of a protein called sirtuin 1 (SIRT1) in cells that build up the lining of small blood vessels in the brain likely contributes to neuroinflammation associated with adrenoleukodystrophy ... Read more

July 16, 2019July 16, 2019

Hyperpigmentation Should Be Considered in Diagnosing X-ALD, Case Report Says

News

Physicians should consider generalized hyperpigmentation, or skin darkening, in the differential diagnosis of patients with adrenoleukodystrophy, a case report suggests. The case report study, “Generalized skin hyperpigmentation as the only ... Read more

April 16, 2019April 16, 2019

Discovery of Signaling Cascade in ALD May Open Door to Trials of Tecfidera

News

Spanish researchers uncovered a signaling cascade involved in nerve degeneration associated with adrenoleukodystrophy in a mouse model of the disease. According to the team, the findings may open the door to ... Read more

January 11, 2019January 11, 2019

Early Diagnosis and Stem Cell Treatment Can Stop CALD Disease Progression, Study Finds

News

Early diagnosis of cerebral adrenoleukodystrophy (CALD), followed by stem cell treatment, can halt disease progression and improve patients’ quality of life, a study finds. The study, “Survival and Functional Outcomes ... Read more