VLCFAs

February 24, 2021August 23, 2022

New Cut-off Levels for Blood VLCFAs May Aid X-ALD Diagnosis

News

Proposed new cut-off levels for values of very long-chain fatty acids, or VLCFAs — whose buildup characterizes X-linked adrenoleukodystrophy (X-ALD) — show higher sensitivity and specificity for detecting genetically confirmed ... Read more

November 18, 2020November 18, 2020

High Biotin Doses Restore Nerve Cell Health in ALD Mice, Study Shows

News

High doses of the B vitamin biotin restored metabolic balance and rescued nerve degradation in a mouse model of adrenoleukodystrophy (ALD), a study found. Based on the finding, the researchers ... Read more

August 26, 2020August 26, 2020

Seizure Diaries for Adrenoleukodystrophy

Health Insight

Seizures are a common symptom of childhood cerebral adrenoleukodystrophy (CALD), especially as the disease progresses. Rare cases of seizures in people with adult-onset adrenoleukodystrophy (ALD) also have been reported. If ... Read more

April 13, 2020April 21, 2020

Tips for Dealing with Hearing Loss in Adrenoleukodystrophy

Health Insight

Adrenoleukodystrophy (ALD) is a severe heritable disorder that primarily affects males. Symptoms can appear early in life. The tissues most affected are nerves and adrenal glands. One symptom that some ... Read more

February 18, 2020February 25, 2020

Researchers Develop Simpler, Faster Method to Screen Newborns for X-ALD

News

Researchers have developed a simpler, faster, reliable method of screening newborns for X-linked adrenoleukodystrophy (X-ALD), which was validated in a North Carolina pilot study. The work suggests that this method could be ... Read more

April 10, 2019April 10, 2019

Cholesterol-derived Molecule 25-HC May Hold Potential for Severe Type of X-ALD

News

Treatment with a naturally occurring cholesterol-derived compound, called 25-hydroxycholesterol (25-HC), may represent a new strategy to prevent the accumulation of long-chain fatty molecules in X-linked adrenoleukodystrophy (X-ALD), results from a ... Read more