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February 8, 2019February 8, 2019

Brain Imaging, Tests Help Diagnose Rare Phenotype of X-linked ALD

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A combination of structural and functional brain imaging and tests assessing cognitive and behavioral functions may help assess damage progression in the frontal part of the brain in adult- onset ... Read more

February 5, 2019February 5, 2019

Risk of Adrenal Insufficiency in ALD Is Greatest from Ages 1-10, Study Says

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Around 80% of males diagnosed with X-linked adrenoleukodystrophy (ALD) will develop adrenal insufficiency, a retrospective study suggests. The risk, although variable with age, is higher during the first 10 years ... Read more

February 1, 2019February 1, 2019

Abnormalities in Bile Acid Production Found in Patient with X-linked ALD, Case Study Reports

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Abnormalities in the production of bile acid — an acid produced by the liver that is responsible for the digestion of dietary fats — were described for the first time ... Read more

January 29, 2019January 29, 2019

Targeted Genetic Testing Is Critical for X-Linked ALD Diagnosis in Atypical Cases, Report Shows

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Targeted genetic testing is critical for accurate diagnosis of X-linked adrenoleukodystrophy (ALD), particularly in cases with atypical presentation, the case of an adult male with mild symptoms demonstrates. The case, ... Read more

January 25, 2019January 25, 2019

Leukodystrophy Diagnosis Less Likely in Children of Racial, Ethnic Minorities

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Children and adolescents of racial or ethnic minorities, such as blacks and Hispanics, are less likely to be diagnosed with a leukodystrophy, according to a recent study. The research, “Association ... Read more

January 22, 2019January 25, 2019

Disease Severity, Transplant Source Influence Long-term Success in Childhood Cerebral X-ALD

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The success of blood stem cell transplants in boys with childhood cerebral X-linked adrenoleukodystrophy (CCALD) is influenced by the severity of white matter loss in the brain and the stem ... Read more

January 18, 2019January 18, 2019

Robust Donor Cell Transplant Required for Blood-brain Barrier Repair in cALD Patients, Study Says

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Robust donor cell transplant is needed for a successful repair of the blood-brain barrier in patients with cerebral adrenoleukodystrophy (cALD), a recent study suggests. The study “Successful donor engraftment and repair of ... Read more

January 15, 2019January 15, 2019

Changes in Cell Lipids May Help Explain Symptom Severity in X-ALD, Study Suggests

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People with X-linked adrenoleukodystrophy (X-ALD) have an imbalance in the production of important fat molecules, or lipids, in their cells that may influence the symptoms and severity of the disease, a ... Read more

January 11, 2019January 11, 2019

Early Diagnosis and Stem Cell Treatment Can Stop CALD Disease Progression, Study Finds

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Early diagnosis of cerebral adrenoleukodystrophy (CALD), followed by stem cell treatment, can halt disease progression and improve patients’ quality of life, a study finds. The study, “Survival and Functional Outcomes ... Read more

January 8, 2019January 8, 2019

Abnormal Immune Response May Underlie Severe Brain Inflammation in Cerebral ALD, Study Suggests

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The abnormal behavior of immune cells called macrophages may be behind the development of cerebral adrenoleukodystrophy (CALD), a violent form of brain inflammation that affects many patients with X-linked adrenoleukodystrophy ... Read more